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    Alfonso BALDI

    Insegnamento di TERAPIA BIOLOGICA DELLE NEOPLASIE

    Corso di laurea magistrale in SCIENZE DEGLI ALIMENTI E DELLA NUTRIZIONE UMANA

    SSD: MED/08

    CFU: 4,00

    ORE PER UNITÀ DIDATTICA: 32,00

    Periodo di Erogazione: Secondo Semestre

    Italiano

    Lingua di insegnamento

    ITALIANO

    Contenuti

    Pathology has always been regarded as the fulcrum of medicine that links the basic disciplines with clinical subjects. In the last twenty years, Pathology has advanced from being an entirely morphological and descriptive subject to one that deals with the most advanced molecular research and is at the front position of research in molecular pathology and cancer. Its study is aimed at elucidating the molecular basis of disease and to the definition of the macroscopic and microscopic phenotypes of the diseases. We can apply this knowledge to improve medical diagnoses and treatment of patients.

    Testi di riferimento

    Robbins & Cotran: Pathologic Basis of Disease
    Stevens, Lowe, Scott: Core Pathology
    Wheater: Basic Histopathology (Atlas)

    Obiettivi formativi

    Il suo studio è volto a chiarire le basi molecolari della malattia e alla definizione dei fenotipi macroscopici e microscopici delle malattie. Possiamo applicare questa conoscenza per migliorare le diagnosi mediche e il trattamento dei pazienti.

    Prerequisiti

    Conoscenza dell'anatomia, istologia e fisiologia degli organi e apparati; conoscenza dei meccanismi patologici di base nelle malattie infiammatorie, infettive, degenerative, immunitarie e neoplastiche

    Metodologie didattiche

    Il metodo didattico si basa essenzialmente sulla descrizione dei principali quadri patologici con il supporto di opportuna iconografia e la presentazione di casi anatomoclinici

    Metodi di valutazione

    Al fine di valutare la conoscenza, la modalità dell'esame è coordinata dalla prova orale. Lo studente dovrebbe essere in grado di descrivere immagini dell'anatomia microscopica riguardanti le malattie più comuni e / o importanti.

    Altre informazioni

    No

    Programma del corso

    1) Conoscenza dei metodi morfologici (citodiagnostica e istopatologica sulla biopsia) utilizzati in clinica e terapia per pazienti, comprese le tecniche utilizzate per la definizione delle caratteristiche molecolari del tessuto patologico esaminato (immunoistochimica, tecniche di biologia molecolare)
    2) Conoscenza dei principi della patologia cellulare (adattamento cellulare a malattia, danno cellulare e morte cellulare)
    3) Conoscenza dell'aspetto macroscopico e microscopico fondamentale dei processi patologici e delle malattie: risposte tissutali al danno (infiammazione acuta e cronica), malattie genetiche e dello sviluppo, neoplasie, immunopatologia di base, malattie infettive, malattie degenerative e multisistemiche
    4) concetti di apprendimento della patologia che aiutano lo studente a correlare i dati anatomo-cilnici e di laboratorio delle condizioni mediche e chirurgiche
    5) Apprendimento di concetti morfologici di base che consentono la comprensione e l'interpretazione da parte del futuro medico del riferimento anatomo-patologico
    6) Conoscenza dei principi di terapia biologica e dei meccanismi molecolari di azione dei farmaci biologici più importanti

    English

    Teaching language

    Italian

    Contents

    Pathology has always been regarded as the fulcrum of medicine that links the basic disciplines with clinical subjects. In the last twenty years, Pathology has advanced from being an entirely morphological and descriptive subject to one that deals with the most advanced molecular research and is at the front position of research in molecular pathology and cancer. Its study is aimed at elucidating the molecular basis of disease and to the definition of the macroscopic and microscopic phenotypes of the diseases. We can apply this knowledge to improve medical diagnoses and treatment of patients.

    Textbook and course materials

    Robbins & Cotran: Pathologic Basis of Disease
    Stevens, Lowe, Scott: Core Pathology
    Wheater: Basic Histopathology (Atlas)

    Course objectives

    Its study is aimed at elucidating the molecular basis of disease and to the definition of the macroscopic and microscopic phenotypes of the diseases. We can apply this knowledge to improve medical diagnoses and treatment of patients.

    Prerequisites

    Knowledge of anatomy, histology and physiology of organs and systems; knowledge of the basic pathological mechanisms in inflammatory, infectious, degenerative, immune and neoplastic diseases

    Teaching methods

    The teaching method is essentially based on the description of the main pathological pictures with the support of appropriate iconography and the presentation of anatomic-clinical cases

    Evaluation methods

    In order to assess the knowledge and the attainment of the objectives, the modality of the examination is characterized by an oral exam, covering all the themes treated in the course. The student should be able also to describe images of microscopic anatomy regarding the most common and/or important diseases.

    Other information

    No

    Course Syllabus

    1) Knowledge of the morphological methods (cytodiagnostic and histopathology on biopsy) used in clinical and therapy for patients, including techniques used of the definition of the molecular characteristics of the pathologic tissue examined (immunohistochemistry, molecular biology techniques)
    2) Knowledge of the principles of cell pathology (cellular adaptation to disease, cell injury and cell death)
    3) Knowledge of the fundamental macroscopic and microscopic appearance of pathological processes and diseases: tissue responses to damage (acute and chronic inflammation), developmental and genetic diseases, neoplasia, basic immunopathology, infectious diseases, degenerative and multisystem diseases
    4) Learning concepts of pathology which helps the student to correlate anatomo-clinical and laboratory data of medical and surgical conditions
    5) Learning of basic morphological concepts that allow understanding and interpreting by the future physician the anatomo-pathologic referral
    6) Knowledge of the principles of target therapy and molecular processes of action of the most important biological drugs

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